Chemotherapy of cancer, treatment of skin diseases and treatment of infections are common use cases of cytostatic drugs.

Cytostatic is a word some doctors and researchers use to describe the way some anti cancer drugs work.

Cytostasis(cyto -cell, stasis -stoppage) is the inhibition of cell growth and multiplication. Cytostatic refers to a cellular component or medicine that inhibits cell growth.

Cytostasis is an important prerequisite for structured multicellular organisms. Without regulation of cell growth and division only unorganized heaps of cells would be possible.

Many cancer drugs aim to kill cancer cells. The word cytotoxic means toxic to cells, or cell killing. So chemotherapy is cytotoxic therapy. Other treatments do not aim to kill cancer cells. They work by stopping the cancer cells from multiplying. So they stop the cancer growing. This is cytostatic therapy. Cytostatic means ‘cell stopping’.

Trends in Medical Research Year: 2007 | Volume: 2 | Issue: 1 | Page No.: 44-50

Cytotoxic effect of Moringa Oleifera leaf extracts on human multiple myeloma cultured cell lines.

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Parvathy MVS, Umamaheshwari A:

J Ethnopharmacol. 2005 May 13;99(1):21-30.

Studies of the anticancer potential of plants used in Bangladeshi folk medicine.

Costa-Lotufo LV, Khan MT, Ather A, Wilke DV, Jimenez PC, Pessoa C, de Moraes ME, de Moraes MO.

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Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza Rua Cel Nunes de Melo 1127, Caixa Postal-3157, 60430-270 Fortaleza Ce, Brazil

Asian Pac J Cancer Prev. 2003 Apr-Jun;4(2):131-9.

Chemomodulatory effect of Moringa oleifera, Lam, on hepatic carcinogen metabolising enzymes, antioxidant parameters and skin papillomagenesis in mice.

Bharali R1, Tabassum J, Azad MR.

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1Department of Biotechnology, Gauhati University, Guwahati 781014, Assam, India.

PLoS One. 2014 Apr 18;9(4):e95492.

Soluble extract from Moringa oleifera leaves with a new anticancer activity.

Jung IL.

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Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, Daejeon, Korea.

Food Chem Toxicol. 2011 Jun;49(6):1270-5..

Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells.

Sreelatha S, Jeyachitra A, Padma PR.

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Faculty of Science, National University of Singapore.

Nutr Cancer. 2011;63(6):971-82. doi: 10.1080/01635581.2011.589960. Epub 2011 Jul 20.

Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2′-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera.

Park EJ1, Cheenpracha S, Chang LC, Kondratyuk TP, Pezzuto JM.

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1College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii 96720, USA.

BMC Complement Altern Med. 2013; 13: 212.

Moringa Oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells

Liron Berkovich, Gideon Earon, Ilan Ron, Adam Rimmon, Akiva Vexler, and Shahar Lev-Ari



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